For anyone flying in from out of town, the best airport to fly into is Medford (MFR).
Definitely recommend renting a car so you can explore all the fun things Southern Oregon has to offer!
There are hotels in Medford and Grants Pass that are 30-45 min from the wedding venue. Alternatively, there are plenty of AirBnB's, Vrbos, and bed and breakfasts in the Applegate Valley (where the wedding venue is).